The Formula
Crescina helps natural
hair growth thanks to the synergic action of its components.
The Crescina formula consists of a dilution in a suitable
hydroalcoholic agent, of a series of functional substances, each
typified by its own individual function and activity, all of them
contributing to rendering the product effective.
The hydroalcoholic agent combined with manual massage
during topical application of Crescina helps these functional substances
to be distributed over the scalp and gently stimulate blood supply
to reach the hair bulb, which is more receptive to being penetrated
by the substances.
The core ingredient of
Crescina Re-Growth is a combination of two amino acids, Cysteine
and Lysine, which are basic components of hair keratin, and
a special growth factor called Glycoprotein, which is able
to promote cell activity (in vitro test) in the bulb cell to stimulate
protein synthesis, especially of keratin, which is the basic protein
found in hair.
An oxygraphy experiment performed on cells in vitro
demonstrated how Crescina's glycoprotein is able to stimulate a
220% increase in oxygen consumption in tested cells compared to
their base values. The amount of intracellular oxygen consumption
is an important parameter for evaluating the stimulating effect
on cell activity.
Cysteine is the amino
acid present in largest quantities in hair. Growth
rate, protein synthesis and hair fibre diameter depend on the availability
of cysteine (Exp. Dermat., 1999, Matheson et al).Tests performed
in vitro show that a drop in cysteine concentration in hair follicles
cultivated in vitro leads to a dose-dependent decrease, both in
the growth rate and in the diameter of the fibre produced. Its presence
is fundamental because during the keratinisation process two cysteine
residues form a cysteine molecule through the creation of a disulphide
bond. These chemical bonds are at the root of the keratin's structural
stability and consequently the hair shaft's mechanical stability.
Eight amino acids are essential for life: that is to
say they must be available in the diet since the organism is not
capable of synthesizing them. If even a single amino acid is lacking
in diet, the organism is forced to break down some of its proteins.
Lysine is an essential amino acid.
It is part of all protein structures and it encourages growth, tissue
repair and production of antibodies, hormones, enzymes. In hair
keratin it is mainly localized in the protein of the root’s
inner shaft which is a very important structure since its function
is to give shape and body to the hair. The proteins in the root
inner sheath and in the hair medulla are stabilized by crucial bonds
between glutamine and lysine, which are responsible for making these
proteins extremely resistant to chemical and enzymatic attack (Molec.
Cell. Bioch., 1984, Peterson et al.).
Together with the two amino acids
cysteine and lysine, glycoprotein coInstitutes what is defined the
“core” of Crescina. The effect of the
alcohol and the vasodilator, as described later, allow the glycoprotein
to permeate the scalp and this has a stimulating effect on the activity
of hair bulb cells in the growth phase. There is also encouragement
of the use of amino acids supplied for protein synthesis, and therefore
for the production hair keratin.
This particular synergy means that Crescina develops its adjuvant
action for natural hair growth in a complete way.
Growth and regrowth of
hair require sufficient nutritional contribution to hair follicles.
It was demonstrated in male subjects suffering early hair loss that
subcutaneous blood flow was 2.6 times slower than in normal subjects
(J. Invest.Dermatol, 1989, Klemp P. et al).
A significant reduction in subcutaneous scalp blood flow in male
subjects suffering early baldness may explain hair loss and subsequent
failure of the hair to grow back.
A temporary blood flow increase in scalp sub-epidermis microcirculation
blood flow, brought about with substances that have vasodilator
and rubefacient effects, encourages trophism in the hair follicle,
which also encourages the penetration of any other components that
may be present.
Local application of benzyl nicotinate
will cause dilation of the hair vessels on the skin that is being
treated and this leads to increased blood flow in situ.
Crescina Re-Growth formula is completed by silicon
and zinc, which are fundamental elements for follicle functioning
and hair growth processes. |
